1.Facultad de Medicina, Universidad Alfonso X, Madrid, Spain
2.Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain
3.Servicio de Histología. Departamento de Investigación, IRYCIS; Hospital Universitario Ramón y Cajal, Madrid, Spain
4.Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas. CSIC, Madrid, Spain
*: pedro.cuevas44@gmail.com
纸质出版:2016-03
Scan QR Code
Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops[J]. MMR, 2016,3(1):51-55.
Pedro Cuevas, Luis Antonio Outeiriño, Carlos Azanza, et al. Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops[J]. Military Medical Research, 2016, 3(1): 51-55.
Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops[J]. MMR, 2016,3(1):51-55. DOI:
Pedro Cuevas, Luis Antonio Outeiriño, Carlos Azanza, et al. Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops[J]. Military Medical Research, 2016, 3(1): 51-55. DOI:
Background:
2
Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of life.
Case presentation:
2
Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study.
Conclusion:
2
To the best of our knowledge
this is the first clinical report of using dobesilate in eye drops. Dobesilate may provide a novel approach to treating drying diseases of the eye.
No authors listed . The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) . Ocul Surf . 2007 ; 5 : 75 - 92 .
Stern ME , Pflugfelder SC . Inflammation in dry eye . Ocul Surf . 2004 ; 2 : 124 - 30 .
Hessen M , Akpek EK . Dry eye: an inflammatory ocular disease . J Ophthalmic Vis Res . 2014 ; 9 : 240 - 50 .
Wei Y , Asbell PA . The core mechanism of dry eye disease is inflammation . Eye Contact Lens . 2014 ; 40 : 248 - 56 .
Niu L , Zhang S , Wu J , Chen L , Wang Y . Upregulation of NLRP3 inflammasome in the tears and ocular surface of dry eye patients . PLoS One . 2015 ; 10 : e0126277 .
Piller NB . Assessment of the anti-inflammatory action of calcium dobesilate. Effect on macrophages attaching to subcutaneously implanted coverslips in guinea pigs . Arzneimittelforschung . 1990 ; 40 : 698 - 700 .
Cuevas P , Angulo J , Giménez-Gallego G . Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea . BMJ Case Rep . 2011 . doi: 10.1136/bcr.08.2011.4579 http://doi.org/10.1136/bcr.08.2011.4579 .
Cuevas P , Angulo J , Giménez-Gallego G . Topical treatment of contact dermatitis by pine processionary caterpillar . BMJ Case Rep . 2011 . doi: 10.1136/bcr.06.2011.4351 http://doi.org/10.1136/bcr.06.2011.4351 .
Angulo J , Cuevas P , Cuevas B , El Youssef M , Fernández A , Martínez-Salamanca E , et al . Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities . J Transl Med . 2015 ; 13 : 48 .
Abetz L , Rajagopalan K , Mertzanis P , Begley C , Barnes R , Chalmers R . Impact of dry eye on everyday Life (IDEEL) study group. Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients . Health Qual Life Outcomes . 2011 ; 9 : 111 .
No authors listed . Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007) . Ocul Surf . 2007 ; 5 : 163 - 78 .
Miljanović B , Dana R , Sullivan DA , Schaumberg DA . Impact of dry eye syndrome on vision-related quality of life . Am J Ophthalmol . 2007 ; 143 : 409 - 15 .
Lin PY , Tsai SY , Cheng CY , Liu JH , Chou P , Hsu WM . Prevalence of dry eye among an elderly Chinese population in Taiwan: the Shihpai Eye Study . Ophthalmology . 2003 ; 110 : 1096 - 101 .
Schaumberg DA , Sullivan DA , Buring JE , Dana MR . Prevalence of dry eye syndrome among US women . Am J Ophthalmol . 2003 ; 136 : 318 - 26 .
Reddy P , Grad O , Rajagopalan K . The economic burden of dry eye: a conceptual framework and preliminary assessment . Cornea . 2004 ; 23 : 751 - 61 .
Stern ME , Beuerman RW , Fox RI , Gao J , Mircheff AK , Pflugfelder SC . The pathology of dry eye: the interaction between the ocular surface and lacrimal glands . Cornea . 1998 ; 17 : 584 - 9 .
Stevenson W , Chauhan SK , Dana R . Dry eye disease: an immune-mediated ocular surface disorder . Arch Ophthalmol . 2012 ; 130 : 90 - 100 .
Gayton JL . Etiology, prevalence, and treatment of dry eye disease . Clin Ophthalmol . 2009 ; 3 : 405 - 12 .
Stevenson D , Tauber J , Reis BL . Efficacy and safety of cyclosporin a ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. The cyclosporin a phase 2 study group . Ophthalmology . 2000 ; 107 : 967 - 74 .
Marsh P , Pflugfelder SC . Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome . Ophthalmology . 1999 ; 106 : 811 - 6 .
Avunduk AM , Avunduk MC , Varnell ED , Kaufman HE . The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients: a clinical and immunocytochemical study . Am J Ophthalmol . 2003 ; 136 : 593 - 602 .
Cordero-Coma M , Anzaar F , Sobrin L , Foster CS . Systemic immunomodulatory therapy in severe dry eye secondary to inflammation . Ocul Immunol Inflamm . 2007 ; 15 : 99 - 104 .
Seal DV , Wright P , Ficker L , Hagan K , Troski M , Menday P . Placebo controlled trial of fusidic acid gel and oxytetracycline for recurrent blepharitis and rosacea . Br J Ophthalmol . 1995 ; 79 : 42 - 5 .
Stern ME , Gao J , Schwalb TA , Ngo M , Tieu DD , Chan CC , et al . Conjunctival T-cell subpopulations in Sjögren’s and non-Sjögren’s patients with dry eye . Invest Ophthalmol Vis Sci . 2002 ; 43 : 2609 - 14 .
Goyal S , Chauhan SK , El Annan J , Nallasamy N , Zhang Q , Dana R . Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity? Arch Ophthalmol . 2010 ; 128 : 819 - 24 .
oyal S , Chauhan SK , Dana R . Blockade of prolymphangiogenic vascular endothelial growth factor C in dry eye disease . Arch Ophthalmol . 2012 ; 130 : 84 - 9 .
Hajrasouliha AR , Sadrai Z , Chauhan SK , Dana R . b-FGF induces corneal blood and lymphatic vessel growth in a spatially distinct pattern . Cornea . 2012 ; 31 : 804 - 9 .
Allain H , Ramelet AA , Polard E , Bentué-Ferrer D . Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids . Drug Saf . 2004 ; 27 : 649 - 60 .
Fernández IS , Cuevas P , Angulo J , López-Navajas P , Canales-Mayordomo A , Lozano RM , et al . Gentisic acid, a compound associated with plant defence and a metabolite of aspirin, heads a new class of in vivo FGF inhibitor . J Biol Chem . 2010 ; 285 : 1714 - 29 .
Andrés G , Leali D , Mitola S , Coltrini D , Camozzi M , Corsini M , et al . A pro-inflammatory signature mediates FGF2-induced angiogenesis . J Cell Mol Med . 2009 ; 13 : 2083 - 108 .
Presta Y , Andrés G , Leali D , Dell’Era P , Ronca R . Inflammatory cells and chemokines sustain FGF2-induced angiogenesis . Eur Cytokine Netw . 2009 ; 20 : 39 - 50 .
Jonca F , Ortega N , Gleizes PE , Bertrand N , Plouet J . Cell release of bioactive fibroblast growth factor 2 by exon 6 encoded sequence of vascular endothelial growth factor . J Biol Chem . 1997 ; 272 : 24203 - 9 .
Mandriota SJ , Pepper MS . Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor . J Cell Sci . 1997 ; 110 : 2293 - 302 .
Angulo J , Peiró C , Romacho T , Fernández A , Cuevas B , González-Corrochano R , et al . Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate . Eur J Pharmacol. 2011 ; 667 : 153-9 .
0
浏览量
15
Downloads
1
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621