Background:Rabies is a zoonosis transmitted via the bites of various mammals

primarily dogs and bats.Known since antiquity

this disease may have the deadliest human fatality rates and is responsible for approximately 65

000 deaths worldwide per year.Case presentation:We report the case details of a 13-year-old boy from India belonging to a South Asian ethnicity

who presented with altered sensorium one month following a dog bite.He did not receive the active rabies immunization and was managed with supportive therapy.The patient had extensive T

2

weighted（T

2

W）/fluid attenuation and inversion recovery（FLAIR） hyper intensities involving the deep gray matter of the cerebral hemispheres

hippocampus

brainstem

and cerebellum.The diagnosis was confirmed by the demonstration of the rabies antigen from a nuchal skin biopsy and a corneal smear.The patient had a slow but significant recovery over four months and was discharged from the hospital in stable condition with severe neurological sequelae.Conclusion:We report a unique case of survival after infection with a universally fatal disease.