Role of the IL-33-ST2 axis in sepsis

Hui Xu; Heth R. Turnquist; Rosemary Hoffman; Timothy R. Billiar

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Role of the IL-33-ST2 axis in sepsis

REVIEW | Updated：2022-12-27

- Role of the IL-33-ST2 axis in sepsis
- Role of the IL-33-ST2 axis in sepsis
- MMR 2017年4卷第1期页码：50-60
- Affiliations：
  
  1.Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
  2.State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  3.Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
- Author bio：
  
  *: billiartr@upmc.edu
- Funds：
  
  the National Institutes of Health(RO1-GM 044100;RO1-GM 050441)
- DOI：
  中图分类号：
- 纸质出版：2017-03
- Accepted：
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Role of the IL-33-ST2 axis in sepsis[J]. MMR, 2017,4(1):50-60.

Hui Xu, Heth R. Turnquist, Rosemary Hoffman, et al. Role of the IL-33-ST2 axis in sepsis[J]. Military Medical Research, 2017, 4(1): 50-60.
Role of the IL-33-ST2 axis in sepsis[J]. MMR, 2017,4(1):50-60. DOI：

Hui Xu, Heth R. Turnquist, Rosemary Hoffman, et al. Role of the IL-33-ST2 axis in sepsis[J]. Military Medical Research, 2017, 4(1): 50-60. DOI：

摘要

Abstract

Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized

it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a recently described member of the IL-1 family that is widely expressed in cells of barrier tissues. Upon tissue damage

IL-33 is released as an alarmin and activates various types of cells of both the innate and adaptive immune system through binding to the ST2/IL-1 receptor accessory protein complex. IL-33 has apparent pleiotropic functions in many disease models

with its actions strongly shaped by the local microenvironment. Recent studies have established a role for the IL-33-ST2 axis in the initiation and perpetuation of inflammation during endotoxemia

but its roles in sepsis appear to be organism and model dependent. In this review

we focus on the recent advances in understanding the role of the IL-33/ST2 axis in sepsis.

关键词

Keywords

references

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