The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances

范谨之; 王正洪

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The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances

Updated：2026-03-12

- The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances
- The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances
- 解放军医学杂志（英文版） 1986年第1期页码：83-86
- Affiliations：
  
  1. Department of Physiology Fourth Military Medical College
  2. ,Xi’an
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1986
- Accepted：
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The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances[J]. 解放军医学杂志（英文版）, 1986,(1):83-86.

[1]范谨之,王正洪.The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances[J].Journal of Medical Colleges of PLA,1986(01):83-86.
The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances[J]. 解放军医学杂志（英文版）, 1986,(1):83-86. DOI：

[1]范谨之,王正洪.The Antagonized Effect of Phentolamine on Endogenous Opiate-Like Substances[J].Journal of Medical Colleges of PLA,1986(01):83-86. DOI：

摘要

Abstract

正

To study the relationship between OLS and adrenergic neurotransmis-sion is the purpose of this work.The inhibitory effect of phentolamine(5×10

-8

M)on OLS was observed.The results showed that on the basiccontraction of myenteric plexus longitudinal muscle（MPLM）

phentolaminehad no direct effects;phentolamine could not antagonize the light dose(2×10

-7

M)of NE-inhibitory on MPLM basic contraction;light dose phento-1amine could antagonize the inhibitory effect of OLS induced by high fre-quence（10Hz）stimulation to the MPLM basic contraction;phentolaminecould potentiate the effect of naloxone in antagonizing the OLS. For re-searching the interaction of adrenergic and enkephalinergic neurotransmis-sion

the present results may be helpful

and also provide a new idea aboutresearching the reeeptokinetics of two types of receptor.

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