Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis

Hong-Da Chen; Bin Lu; Ju-Fang Shi; Yue-Yang Zhou; Ling-Bin Du; Xian-Zhen Liao; Dong-Hua Wei; Dong Dong; Yi Gao; Chen Zhu; Rong-Biao Ying; Wei-Fang Zheng; Shi-Peng Yan; Hai-Fan Xiao; Juan Zhang; Yun-Xin Kong; Fu-Rong Li; Na Li; Jia-Hui Luo; Chen-Yu Luo; Hermann Brenner; Min Dai

doi:10.1186/s40779-025-00671-7

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Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis

RESEARCH | Updated：2025-12-04

- Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis
- “In a population-based colorectal cancer screening trial, risk-adapted screening, colonoscopy, and fecal immunochemical test demonstrated comparable effectiveness, but differed in participation rates, resource utilization, and cost-effectiveness. Risk-adapted screening could serve as a complementary approach to established strategies, particularly when health resources are limited.”
- Military Medical Research Vol. 12, (2025)
- Affiliations：
  
  1.Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  2.Department of Cancer Epidemiol-ogy, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  3.Office of Cancer Screening, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  4.Department of Cancer Prevention, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
  5.Department of Cancer Prevention, Hunan Cancer Hospital, Changsha 410013, China
  6.Department of Cancer Prevention, Anhui Provincial Cancer Hospital, Hefei 230031, China
  7.Office of Cancer Preven-tion and Treatment, Xuzhou Cancer Hospital, Xuzhou 221005, Jiangsu, China
  8.Department of Colorectum Surgery, Tumor Hospital of Yunnan Province, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
  9.Department of Surgical Oncology, Taizhou Cancer Hospital, Taizhou 317502, Zhejiang, China
  10.Department of Anorectal Diseases, Lanxi Hospital of Tradi-tional Chinese Medicine, Jinhua 321100, Zhejiang, China
  11.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Baden-Württemberg, Germany
  12.German Cancer Con-sortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Baden-Württemberg, Germany
- Author bio：
  
  * Hong-Da Chen chenhongda@pumch.cn
  Min Dai daimin2002@hotmail.com
- Funds：
- DOI：10.1186/s40779-025-00671-7
  CLC：
- Received：19 June 2025，
  
  Accepted：04 November 2025，
  
  Online First：24 November 2025，
  
  Published：2025
- Accepted：
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Hong-Da Chen, Bin Lu, Ju-Fang Shi, et al. Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis[J/OL]. Military Medical Research, 2025, 12.
DOI：

Hong-Da Chen, Bin Lu, Ju-Fang Shi, et al. Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00671-7.

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Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis

DOI：10.1186/s40779-025-00671-7