Cell-free DNA in sepsis: from molecular insights to clinical management

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Cell-free DNA in sepsis: from molecular insights to clinical management

REVIEW | Updated：2026-01-29

- Cell-free DNA in sepsis: from molecular insights to clinical management
- “In the field of sepsis diagnosis and treatment, cell-free DNA (cfDNA) has emerged as a novel biomarker and molecular therapeutic target. Expert research has elucidated the release and pathological mechanisms of cfDNA in sepsis, laying a foundation for the development of targeted treatment strategies.”
- Military Medical Research Vol. 12, (2025)
- Affiliations：
  
  1.Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  2.Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China
- Author bio：
  
  * Shi-Chu Xiao huangzhuoxiao@sohu.com
  Zhao-Fan Xia xiazhaofan_smmu@163.com
  Yong-Jun Zheng zhengyongjun@smmu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00668-2
  CLC：
- Received：30 July 2025，
  
  Accepted：01 November 2025，
  
  Online First：02 December 2025，
  
  Published：2025
- Accepted：
Scan QR Code
Lei Li, Hong-Chao Huang, Yin He, et al. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025, 12.
DOI：

Lei Li, Hong-Chao Huang, Yin He, et al. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00668-2.

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