TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

Kai-Zhao Chen; Zi-Yang Lin; Long-Jun Chen; You-Xi Zhou; Wei Zhang; Hao-Yang Wan; Yong-Kun Huo; Qi Fu; Zi-Qing Gao; Hong-Wei Cheng; Xiao-Dong Ma; Shuai-Shuai Zhang

doi:10.1186/s40779-025-00667-3

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TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

RESEARCH | Updated：2026-06-10

- TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice
- Military Medical Research Vol. 13, Issue 5, Pages: 706-727(2026)
- Affiliations：
  
  1.Key Laboratory of Brain, Cognition and Education Sciences, Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Ministry of Education, South China Normal University, Guangzhou 510631, China
  2.Zhuhai UM Science and Technology Research Institute, University of Macau, Macau 999078, China
  3.State Key Laboratory of Vaccine for Infectious Diseases, Xiang an Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, Fujian Engineering Research Center of Molecular Theranostic Technology, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China
- Author bio：
  
  * Hong-Wei Cheng zumri.hwcheng@um.edu.mo
  Xiao-Dong Ma maxiaodong@m.scnu.edu.cn
  Shuai-Shuai Zhang zhangshuai2@scnu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00667-3
  CLC：
- Received：27 June 2025，
  
  Accepted：31 October 2025，
  
  Online First：11 November 2025，
  
  Published：2026-05
- Accepted：
Scan QR Code
Kai-Zhao Chen, Zi-Yang Lin, Long-Jun Chen, et al. TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice[J]. Military Medical Research, 2026, 13(5): 706-727.
DOI：

Kai-Zhao Chen, Zi-Yang Lin, Long-Jun Chen, et al. TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice[J]. Military Medical Research, 2026, 13(5): 706-727. DOI： 10.1186/s40779-025-00667-3.

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TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

DOI：10.1186/s40779-025-00667-3