Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

Shuang-Qing Wang; Ming-Ji Jin; Ze-Ke Guo; Dong-Ri Shen; Li-Na Jin; Fang Cheng; Yan-Ru Zhao; Teng Liu; Yu-Cai Li; Nuo-Ya Wang; Ling-Qing Chen; Wei Huang; Xiu-Quan Quan; Zhong-Gao Gao

doi:10.1186/s40779-025-00658-4

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Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

RESEARCH | Updated：2026-06-10

- Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry
- Military Medical Research Vol. 13, Issue 4, Pages: 559-587(2026)
- Affiliations：
  
  1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sci-ences and Peking Union Medical College, Beijing 100050, China
  2.Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  3.Langfang Kangbao Huitai Biotechnology Co. Ltd, Langfang 065001, Hebei, China
  4.Lan-Jayeon Medical Device Co., Ltd, Beijing 100050, China
  5.Emergency Depart-ment, Yanbian University Hospital, Yanji, Jilin 133000, China
- Author bio：
  
  * Zhong-Gao Gao zggao@imm.ac.cn
- Funds：
- DOI：10.1186/s40779-025-00658-4
  CLC：
- Received：12 May 2025，
  
  Accepted：02 October 2025，
  
  Online First：28 October 2025，
  
  Published：2026-04
- Accepted：
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Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587.
DOI：

Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587. DOI： 10.1186/s40779-025-00658-4.

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Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

DOI：10.1186/s40779-025-00658-4