Serum immunoglobulin G predicts mortality and stratifies intravenous immunoglobulin benefit in sepsis patients

Yuan-Yuan Hu; Ming-Min Pang; Hao-Yu Wang; Wen-Xiong Li; Hao Wang

doi:10.1186/s40779-025-00657-5

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Serum immunoglobulin G predicts mortality and stratifies intravenous immunoglobulin benefit in sepsis patients

LETTER TO THE EDITOR | Updated：2026-05-08

- Serum immunoglobulin G predicts mortality and stratifies intravenous immunoglobulin benefit in sepsis patients
- Military Medical Research Vol. 13, Issue 3, Pages: 511-514(2026)
- Affiliations：
  
  1.Department of Critical Care Medicine, Qilu Hospital, Shandong University, Jinan 250012, China
  2.Innovation Research Center for Sepsis and Multiple Organ Injury, Shandong University, Jinan 250012, China
  3.Department of Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- Author bio：
  
  * Wen-Xiong Li liwenxiong@mail.ccmu.edu.cn
  Hao Wang wanghao34@email.sdu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00657-5
  CLC：
- Received：20 June 2025，
  
  Accepted：28 September 2025，
  
  Online First：23 October 2025，
  
  Published：2026-03
- Accepted：
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Yuan-Yuan Hu, Ming-Min Pang, Hao-Yu Wang, et al. Serum immunoglobulin G predicts mortality and stratifies intravenous immunoglobulin benefit in sepsis patients[J]. Military Medical Research, 2026, 13(3): 511-514.
DOI：

Yuan-Yuan Hu, Ming-Min Pang, Hao-Yu Wang, et al. Serum immunoglobulin G predicts mortality and stratifies intravenous immunoglobulin benefit in sepsis patients[J]. Military Medical Research, 2026, 13(3): 511-514. DOI： 10.1186/s40779-025-00657-5.

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Venet F , Monneret G . Advances in the understanding and treatment of sepsis‑induced immunosuppression . Nat Rev Nephrol . 2018 ; 14 ( 2 ): 121 – 37 .

Pei F , Yao RQ , Ren C , Bahrami S , Billiar TR , Chaudry IH , et al . Expert consen‑sus on the monitoring and treatment of sepsis‑induced immunosuppres‑sion . Mil Med Res . 2022 ; 9 ( 1 ): 74 .

Evans L , Rhodes A , Alhazzani W , Antonelli M , Coopersmith CM , French C , et al . Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 . Crit Care Med . 2021 ; 49 ( 11 ): e1063 – 143 .

Alejandria MM , Lansang MA , Dans LF , 3rd Mantaring JB. . Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock . Cochrane Database Syst Rev . 2013 ; 2013 ( 9 ): CD001090 .

Werdan K , Pilz G , Bujdoso O , Fraunberger P , Neeser G , Schmieder RE , et al . Score‑based immunoglobulin G therapy of patients with sepsis: the SBITS study . Crit Care Med . 2007 ; 35 ( 12 ): 2693 – 701 .

Yang Y , Yu X , Zhang F , Xia Y . Evaluation of the effect of intravenous immunoglobulin dosing on mortality in patients with sepsis: a network meta‑analysis . Clin Ther . 2019 ; 41 ( 9 ): 1823 ‑ 38.e4 .

Madsen MB , Hjortrup PB , Hansen MB , Lange T , Norrby‑Teglund A , Hylde‑gaard O , et al . Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo‑controlled trial . Intensive Care Med . 2017 ; 43 ( 11 ): 1585 – 93 .

Antcliffe DB , Burrell A , Boyle AJ , Gordon AC , McAuley DF , Silversides J . Sepsis subphenotypes, theragnostics and personalized sepsis care . Inten‑sive Care Med . 2025 ; 51 ( 4 ): 756 – 68 .

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