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Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior
RESEARCH | Updated：2025-10-14

    • Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior

    • “In the realm of nanomedicine, a study has made strides by examining the impact of PEGylation levels on the performance of SN38 prodrug nanoparticles. Expert researchers systematically evaluated varying PEGylation levels, which significantly influence stability, drug release, cytotoxicity, and antitumor efficacy. High PEGylation at 150% NPs demonstrated superior antitumor effects and minimal intestinal toxicity, offering a promising solution for enhancing the delivery and safety of chemotherapy drugs.”
    • Military Medical Research   Vol. 12, (2025)

    • DOI：10.1186/s40779-025-00648-6    

      CLC：

    • Received：24 December 2024，

      Accepted：08 September 2025，

      Online First：22 September 2025，

      Published：2025

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  • Ya-Qiao Li, Zhi-Yu Kuang, Bao-Yuan Zhang, et al. Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00648-6.

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