Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity

Meng-Die Yang; Chun-Yan Zhu; Gang Yang; Xiao-Yi Zhang; Yi Zhu; Miao Chen; Jia-Jia Zhang; Ling Bai; Shan-Shan Qin; Chao Ma; Fei Yu; Kun Zhang

doi:10.1186/s40779-025-00647-7

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Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity

RESEARCH | Updated：2025-10-14

- Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity
- “In the field of targeted radionuclide therapy, researchers have developed a radiopharmaceutical with multienzymatic catalysis activities, which can disrupt tumor lipid metabolic homeostasis and enhance antitumor immunity. This research provides a new direction for improving the efficacy of targeted radionuclide therapy.”
- Military Medical Research Vol. 12, (2025)
- Affiliations：
  
  1.Department of Nuclear Medicine, Shanghai Tenth People’s Hospital and Institute of Nuclear Medicine, School of Medicine, Tongji University, Shanghai 200072, China
  2.Central Laboratory, Department of Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
  3.Department of Nuclear Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
  4.Department of Pathology, School of Medicine, Duke University, Durham, NC 27710, USA
- Author bio：
  
  * Fei Yu yufei_021@163.com; 0910110013yufei@tongji.edu.cn
  Kun Zhang zhang1986kun@tongji.edu.cn; zhang1986kun@126.com
- Funds：
- DOI：10.1186/s40779-025-00647-7
  CLC：
- Received：28 February 2025，
  
  Accepted：04 September 2025，
  
  Online First：19 September 2025，
  
  Published：2025
- Accepted：
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Meng-Die Yang, Chun-Yan Zhu, Gang Yang, et al. Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity[J/OL]. Military Medical Research, 2025, 12.
DOI：

Meng-Die Yang, Chun-Yan Zhu, Gang Yang, et al. Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00647-7.

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Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity

DOI：10.1186/s40779-025-00647-7