ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

Yu Duan; Ze-Chen Shan; Jiao-Jiao Pang; Yu-Guo Chen

doi:10.1186/s40779-025-00646-8

Your Location：

Home >

Browse articles >

ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

REVIEW | Updated：2026-03-26

- ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases
- “A new review introduces research progress in the field of aldehyde dehydrogenase 2 (ALDH2). Experts explored the regulatory mechanisms through which ALDH2 affects autophagy and cell death pathways, providing a novel theoretical framework for human disease treatment.”
- Military Medical Research Vol. 13, Issue 2, Pages: 239-266(2026)
- Affiliations：
  
  1.Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
  2.Chest Pain Center, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan 250000, China
  3.Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
  4.The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan 250000, China
- Author bio：
  
  * Jiao-Jiao Pang jiaojiaopang@email.sdu.edu.cn
  Yu-Guo Chen chen919085@sdu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00646-8
  CLC：
- Received：31 March 2025，
  
  Accepted：28 August 2025，
  
  Online First：18 September 2025，
  
  Published：2026-02
- Accepted：
Scan QR Code
Yu Duan, Ze-Chen Shan, Jiao-Jiao Pang, et al. ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases[J]. Military Medical Research, 2026, 13(2): 239-266.
DOI：

Yu Duan, Ze-Chen Shan, Jiao-Jiao Pang, et al. ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases[J]. Military Medical Research, 2026, 13(2): 239-266. DOI： 10.1186/s40779-025-00646-8.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Advances in the mechanism of small nucleolar RNA and its role in DNA damage response

TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells

Related Author

Li-Ping Shen

Wen-Cheng Zhang

Jia-Rong Deng

Zhen-Hua Qi

Zhong-Wu Lin

Zhi-Dong Wang

Yi Zhuo

Wen-Shui Li

Related Institution

Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China

Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine

First Clinical Department of Changsha Medical University

NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital

Department of Neurology, the Second Xiangya Hospital, Central South University

⁰

ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

DOI：10.1186/s40779-025-00646-8