Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia
RESEARCH|Updated:2026-03-26
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia
“A new study introduces research progress in the field of antipsychotic-induced movement disorders (AIMDs). Experts conducted a genome-wide association study (GWAS) across multiple cohorts, identifying key genetic loci associated with AIMDs. The findings highlight the role of substantia nigra related gene polymorphisms in AIMDs, opening a new direction for personalized treatment approaches in schizophrenia.”
Military Medical ResearchVol. 13, Issue 2, Pages: 185-197(2026)
Affiliations:
1.Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing 100191, China
2.PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
3.Chinese Institute for Brain Research, Beijing 102206, China
Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, et al. Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia[J]. Military Medical Research, 2026, 13(2): 185-197.
DOI:
Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, et al. Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia[J]. Military Medical Research, 2026, 13(2): 185-197. DOI: 10.1186/s40779-025-00636-w.
Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia