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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
RESEARCH | Updated：2026-03-26

    • Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

    • “A new study explores the role of IL-33 in repetitive mild traumatic brain injury (rmTBI). Researchers used an rmTBI mouse model to investigate how IL-33 affects cognitive function and neuroinflammation. The study found that IL-33 enhances microglial phagocytosis and reduces neuronal damage, suggesting it could be a therapeutic target for improving neurological outcomes in rmTBI.”
    • Military Medical Research   Vol. 13, Issue 1, Pages: 24-42(2026)

    • DOI：10.1186/s40779-025-00631-1    

      CLC：

    • Received：06 November 2024，

      Accepted：16 July 2025，

      Online First：05 August 2025，

      Published：2026-01

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  • Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, et al. Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis[J]. Military Medical Research, 2026, 13(1): 24-42. DOI： 10.1186/s40779-025-00631-1.

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