Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids

Cong-Yi Shen; Qi-Rong Zhou; Xiang Wu; Xin-Yu Han; Qin Zhang; Xiao Chen; Yu-Xiao Lai; Long Bai; Ying-Ying Jing; Jian-Hua Wang; Cheng-Long Wang; Zhen Geng; Jia-Can Su

doi:10.1186/s40779-025-00625-z

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Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids

RESEARCH | Updated：2026-03-26

- Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids
- “Introducing research progress in the field of cartilage repair. Experts have developed a DNA-silk fibroin hydrogel sustained-release system (DSRGT) to construct cartilage organoids (COs). This innovative strategy provides solutions to solve prolonged repair cycles and suboptimal outcomes in cartilage repair.”
- Military Medical Research Vol. 13, Issue 1, Pages: 1-23(2026)
- Affiliations：
  
  1.Institute of Translational Medicine, Shanghai University, Shanghai 200444, China
  2.MedEng-X Institutes, Shanghai University, Shanghai 200444, China
  3.Organoid Research Center, Shanghai University, Shanghai 200444, China
  4.School of Medicine, Shanghai University, Shanghai 200444, China
  5.National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China
  6.Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  7.Centre for Translational Medicine Research and Development, Institute of Bio-medical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
- Author bio：
  
  * Jian-Hua Wang shwangjianhua@gmail.com
  Cheng-Long Wang wangorth@163.com
  Zhen Geng nanboshan1987@163.com
  Jia-Can Su drsujiacan@163.com
- Funds：
- DOI：10.1186/s40779-025-00625-z
  CLC：
- Received：08 January 2025，
  
  Accepted：03 July 2025，
  
  Online First：28 July 2025，
  
  Published：2026-01
- Accepted：
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Cong-Yi Shen, Qi-Rong Zhou, Xiang Wu, et al. Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids[J]. Military Medical Research, 2026, 13(1): 1-23.
DOI：

Cong-Yi Shen, Qi-Rong Zhou, Xiang Wu, et al. Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids[J]. Military Medical Research, 2026, 13(1): 1-23. DOI： 10.1186/s40779-025-00625-z.

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Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids

DOI：10.1186/s40779-025-00625-z