Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia
RESEARCH|Updated:2025-12-13
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Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia
“Reporting on the latest research in the field of benign prostatic hyperplasia (BPH), experts have established a novel link between microbial presence and prostatic fibrosis. The study, which provides solutions to address the ineffectiveness of current BPH treatments, verified that Salmonella enterica promotes prostatic fibrosis through ALKBH5-m6A-GPX4-mediated ferroptosis, laying a foundation for the construction of new therapeutic targets and personalized strategies.”
Military Medical ResearchVol. 12, Issue 9, Pages: 1350-1368(2025)
Affiliations:
1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2.Department of Gastrointestinal Surgery, the First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China
3.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
4.Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China
5.Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
6.Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, et al. Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia[J]. Military Medical Research, 2025, 12(9): 1350-1368.
DOI:
Cong Zhu, Lu-Yao Li, Ming-Hui Shi, et al. Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia[J]. Military Medical Research, 2025, 12(9): 1350-1368. DOI: 10.1186/s40779-025-00614-2.
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