Endovascular treatment for cerebral venous thrombosis: a multicenter study in China

He-Tao Bian; Xia Wang; Gui-You Liu; Chen Zhou; Ran Meng; Lan Liu; Jian-Gang Duan; Feng Yan; Chuan-Hui Li; Min Li; Wen Hui; Xu-Xiang Zhang; Dong Zhao; Ya-Peng Li; Qi Fang; De-Zhi Kang; Hong-Liang Zeng; Zhi-Jian Liang; Zheng-Hao Shi; Wei Yue; Qin-Jian Sun; Gui-Sheng Chen; Jian-Long Song; Zhong-Rui Yan; Qiu-Hong Ji; Kai-Jie Wang; Lu-Sha Tong; Xiao Hu; Wen-Feng Cao; Wei Yan; Rui-Jiang Gao; Qi Li; Jian-Yi Wang; Yi Liu; Bao-Jun Wang; Xiao-Hua Wang; Sheng-Tao Yao; Ye Lang; Hai-Peng Li; Craig S. Anderson; Xun-Ming Ji

doi:10.1186/s40779-025-00605-3

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Endovascular treatment for cerebral venous thrombosis: a multicenter study in China

RESEARCH | Updated：2026-05-08

- Endovascular treatment for cerebral venous thrombosis: a multicenter study in China
- Military Medical Research Vol. 13, Issue 3, Pages: 345-352(2026)
- Affiliations：
  
  1.Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China
  2.The George Institute for Global Health, University of New South Wales, Sydney 2000, Australia
  3.Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  4.School of Statistics, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA
  5.Department of Emergency, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  6.Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  7.Department of Neurology and Stroke Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  8.Department of Science and Technology, West China Hospital of Sichuan University, Chengdu 610041, China
  9.Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  10.Department of Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing 100013, China
  11.Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China
  12.Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
  13.Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
  14.Department of Neurology, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi, China
  15.Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Xining 530021, China
  16.Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  17.Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China
  18.Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
  19.Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750001, China
  20.Department of Neurology, the First Affiliated Hospital of USTC, Hefei 230001, China
  21.Department of Neurology, Jining First People’s Hospital, Jining 272113, Shandong, China
  22.Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
  23.Department of Neurology, Tangshan Gongren Hospital, Tangshan 063099, Hebei, China
  24.Department of Neurology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
  25.Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, China
  26.Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China
  27.Department of Neurology, the First People’s Hospital of Kashi, Kashi 84000, Xinjiang, China
  28.Department of Neurology, Inner Mongolia People’s Hospital, Hohhot 010010, China
  29.Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
  30.Department of Neurology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
  31.Department of Neurology, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
  32.Department of Neurology, Baotou Central Hospital Inner Mongolia, Baotou 014040, Inner Mongolia Autonomous Region, China
  33.Department of Neurology, Qujing No. 1 Hospital, Qujing 655000, Yunnan, China
  34.Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou, China
  35.Department of Neurology, Shengli Oilfield Central Hospital, Dongying 257100, Shandong, China
  36.Department of Neurology, the First People’s Hospital of Chenzhou, Chenzhou 424300, Hunan, China
  37.Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai 200433, China
- Author bio：
  
  * Xun-Ming Ji jixm@ccmu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00605-3
  CLC：
- Received：17 November 2024，
  
  Accepted：19 March 2025，
  
  Online First：08 April 2025，
  
  Published：2026-03
- Accepted：
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He-Tao Bian, Xia Wang, Gui-You Liu, et al. Endovascular treatment for cerebral venous thrombosis: a multicenter study in China[J]. Military Medical Research, 2026, 13(3): 345-352.
DOI：

He-Tao Bian, Xia Wang, Gui-You Liu, et al. Endovascular treatment for cerebral venous thrombosis: a multicenter study in China[J]. Military Medical Research, 2026, 13(3): 345-352. DOI： 10.1186/s40779-025-00605-3.

摘要

Abstract

Background

Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT)

but the evidence supporting its efficacy and safety is limited.

Methods

This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. Propensity score weighting models were used to adjust baseline confounding variables to determine the association of EVT on the primary outcome of good functional status

defined as score 0-1 on the modified Rankin Scale after hospital discharge.

Results

Of 3063 patients identified through hospital records searches

2774 adults [age (42±15.8) years

female 50.3%

]

fulfilled eligibility criteria and agreed to be included

of whom 449 (16.2%) received EVT and 2325 (83.8%) received standard care. There was no significant difference between the EVT group and the standard care group in terms of the possibility of good functional recovery [weighted risk ratio = 1.00

95% confidence interval (CI)0.96-1.03

]

. Similarly

there was no d

ifference in the likelihood of death at hospital discharge (weighted risk ratio = 1.91

95% CI 0.91-3.68). In subgroup analysis

the possibility of good functional recovery was lower in patients with intracerebral hemorrhage (weighted risk ratio = 0.88

95% CI 0.79-0.98;

for interaction = 0.01) and seizures(weighted risk ratio = 0.86

95% CI 0.76-0.95;

for interaction = 0.03).

Conclusion

In this large nationwide study

EVT was not associated with improved functional outcomes compared to standard care in patients with CVT.

关键词

Keywords

references

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