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Endovascular treatment for cerebral venous thrombosis: a multicenter study in China
- Military Medical Research Vol. 12, (2025)
- Affiliations：
1.Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China
2.The George Institute for Global Health, University of New South Wales, Sydney 2000, Australia
3.Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China
4.School of Statistics, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA
5.Department of Emergency, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
6.Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
7.Department of Neurology and Stroke Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
8.Department of Science and Technology, West China Hospital of Sichuan University, Chengdu 610041, China
9.Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
10.Department of Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing 100013, China
11.Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China
12.Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
13.Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
14.Department of Neurology, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi, China
15.Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Xining 530021, China
16.Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
17.Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China
18.Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
19.Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750001, China
20.Department of Neurology, the First Affiliated Hospital of USTC, Hefei 230001, China
21.Department of Neurology, Jining First People’s Hospital, Jining 272113, Shandong, China
22.Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
23.Department of Neurology, Tangshan Gongren Hospital, Tangshan 063099, Hebei, China
24.Department of Neurology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
25.Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, China
26.Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang 330006, China
27.Department of Neurology, the First People’s Hospital of Kashi, Kashi 84000, Xinjiang, China
28.Department of Neurology, Inner Mongolia People’s Hospital, Hohhot 010010, China
29.Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
30.Department of Neurology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
31.Department of Neurology, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
32.Department of Neurology, Baotou Central Hospital Inner Mongolia, Baotou 014040, Inner Mongolia Autonomous Region, China
33.Department of Neurology, Qujing No. 1 Hospital, Qujing 655000, Yunnan, China
34.Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou, China
35.Department of Neurology, Shengli Oilfield Central Hospital, Dongying 257100, Shandong, China
36.Department of Neurology, the First People’s Hospital of Chenzhou, Chenzhou 424300, Hunan, China
37.Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai 200433, China
- Author bio：
* Xun-Ming Ji jixm@ccmu.edu.cn
- Funds：
DOI：10.1186/s40779-025-00605-3
CLC：Received：17 November 2024，
Accepted：19 March 2025，
Online First：08 April 2025，
Published：2025
- Accepted：
Scan QR Code
He-Tao Bian, Xia Wang, Gui-You Liu, et al. Endovascular treatment for cerebral venous thrombosis: a multicenter study in China[J/OL]. Military Medical Research, 2025, 12.
He-Tao Bian, Xia Wang, Gui-You Liu, et al. Endovascular treatment for cerebral venous thrombosis: a multicenter study in China[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00605-3.
摘要
Abstract
Background
2
Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT)
but the evidence supporting its efficacy and safety is limited.
Methods
2
This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. Propensity score weighting models were used to adjust baseline confounding variables to determine the association of EVT on the primary outcome of good functional status
defined as score 0-1 on the modified Rankin Scale after hospital discharge.
Results
2
Of 3063 patients identified through hospital records searches
2774 adults [age (42±15.8) years
female 50.3%
]
fulfilled eligibility criteria and agreed to be included
of whom 449 (16.2%) received EVT and 2325 (83.8%) received standard care. There was no significant difference between the EVT group and the standard care group in terms of the possibility of good functional recovery [weighted risk ratio = 1.00
95% confidence interval (CI)0.96-1.03
]
. Similarly
there was no difference in the likelihood of death at hospital discharge (weighted risk ratio = 1.91
95% CI 0.91-3.68
). In subgroup analysis
the possibility of good functional recovery was lower in patients with intracerebral hemorrhage (weighted risk ratio = 0.88
95% CI 0.79-0.98;
P
for interaction = 0.01) and seizures(weighted risk ratio = 0.86
95% CI 0.76-0.95;
P
for interaction = 0.03).
Conclusion
2
In this large nationwide study
EVT was not associated with improved functional outcomes compared to standard care in patients with CVT.
关键词
Keywords
references
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