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Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies
REVIEW | Updated：2025-12-13

    • Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

    • “In the field of bone research, this paper reviews the connection between the nervous system and bone metabolism, either intact or after injury. It explores the relationship between specific brain nuclei and bone homeostasis, the characteristics of bone innervation and nerve subtypes, and the molecular features and regulatory functions of these nerves. The paper also summarizes available translational approaches that utilize nerve function to improve bone homeostasis and promote bone regeneration.”
    • Military Medical Research   Vol. 12, Issue 10, Pages: 1645-1666(2025)

    • DOI：10.1186/s40779-025-00600-8    

      CLC：

    • Received：02 October 2024，

      Accepted：04 March 2025，

      Online First：20 March 2025，

      Published：2025-10

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  • Tong-Zhou Liang, Zhe-Yu Jin, Yue-Jun Lin, et al. Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies[J]. Military Medical Research, 2025, 12(10): 1645-1666. DOI： 10.1186/s40779-025-00600-8.

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