Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence

Muhammad Tufail; Can-Hua Jiang; Ning Li

doi:10.1186/s40779-025-00595-2

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Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence

REVIEW | Updated：2025-12-13

- Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence
- “In the battle against cancer, understanding tumor dormancy is crucial. This review delves into the cellular, angiogenic, and immunological aspects of dormancy, shedding light on current therapeutic strategies targeting dormant cells, including combination therapies and immunotherapies, which could prevent cancer recurrence and improve patient outcomes.”
- Military Medical Research Vol. 12, Issue 9, Pages: 1456-1491(2025)
- Affiliations：
  
  1.Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China
  2.Institute of Oral Precancerous Lesions, Central South University, Changsha 410008, China
  3.Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha 410008, China
  4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
- Author bio：
  
  * Ning Li liningoms@csu.edu.cn
- Funds：
- DOI：10.1186/s40779-025-00595-2
  CLC：
- Received：10 July 2024，
  
  Accepted：26 January 2025，
  
  Online First：11 February 2025，
  
  Published：2025-09
- Accepted：
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Muhammad Tufail, Can-Hua Jiang, Ning Li. Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence[J]. Military Medical Research, 2025, 12(9): 1456-1491.
DOI：

Muhammad Tufail, Can-Hua Jiang, Ning Li. Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence[J]. Military Medical Research, 2025, 12(9): 1456-1491. DOI： 10.1186/s40779-025-00595-2.

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Tumor dormancy and relapse:understanding the molecular mechanisms of cancer recurrence

DOI：10.1186/s40779-025-00595-2