MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

Bu-Fu Tang; Wang-Ting Xu; Shi-Ji Fang; Jin-Yu Zhu; Rong-Fang Qiu; Lin Shen; Yang Yang; Qiao-You Weng; Ya-Jie Wang; Jia-Yi Ding; Xiao-Jie Zhang; Wei-Qian Chen; Li-Yun Zheng; Jing-Jing Song; Biao Chen; Zhong-Wei Zhao; Min-Jiang Chen; Jian-Song Ji

doi:10.1186/s40779-024-00588-7

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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

RESEARCH | Updated：2025-12-13

- MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies
- “In the field of liver cancer treatment, researchers have made significant progress. They found that radiofrequency ablation (RFA) treatment upregulated MELK expression, and MELK inhibition promoted RFA efficacy by immunogenic cell death and the antitumor response. Targeting MELK via RGD-LNPs provides new insight into improving RFA efficacy in HCC clinical treatment and combating the malignant progression of liver cancer.”
- Military Medical Research Vol. 12, Issue 7, Pages: 1046-1064(2025)
- Affiliations：
  
  1.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China
  2.Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China
  3.Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
  4.Department of Pulmonary and Critical Care Medicine, Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
  5.Clinical College of the Affiliated Central Hospital, School of Medicine, Lishui University, Lishui 323000, Zhejiang, China
- Author bio：
  
  * zhaozw79@163.com
  minjiangchen@wmu.edu.cn
  jijiansong@zju.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00588-7
  CLC：
- Published：2025-07
- Accepted：
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Cite this article as: Tang BF, Xu WT, Fang SJ, Zhu JY, Qiu RF, Shen L, et al. MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies. Mil Med Res. 2025;12(1):5.
DOI：

Cite this article as: Tang BF, Xu WT, Fang SJ, Zhu JY, Qiu RF, Shen L, et al. MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies. Mil Med Res. 2025;12(1):5. DOI： 10.1186/s40779-024-00588-7.

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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

DOI：10.1186/s40779-024-00588-7