Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

Yogesh Godiyal; Drishti Maheshwari; Hiroaki Taniguchi; Shweta S. Zinzuwadia; Yanelys Morera-Díaz; Devesh Tewari; Anupam Bishayee

doi:10.1186/s40779-024-00586-9

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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

REVIEW | Updated：2025-12-13

- Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy
- “In the fight against cancer, a review paper highlights the potential of natural compounds targeting the PD-1/PD-L1 pathway, offering a new direction for cancer research.”
- Military Medical Research Vol. 12, Issue 10, Pages: 1567-1616(2025)
- Affiliations：
  
  1.Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India
  2.Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec,05-552 Magdalenka, Poland
  3.African Genome Center, Mohammed VI Polytechnic University, Hay Moulay Rachid, 43150 Ben Guerir, Morocco
  4.Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
  5.Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, 11600 Havana, Cuba
- Author bio：
  
  * Devesh Tewari devesh.tewari@dpsru.edu.in; dtewari3@gmail.com
  Anupam Bishayee abishayee@lecom.edu; abishayee@gmail.com
- Funds：
- DOI：10.1186/s40779-024-00586-9
  CLC：
- Received：08 July 2024，
  
  Accepted：29 November 2024，
  
  Online First：18 December 2024，
  
  Published：2025-10
- Accepted：
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Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, et al. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025, 12(10): 1567-1616.
DOI：

Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, et al. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025, 12(10): 1567-1616. DOI： 10.1186/s40779-024-00586-9.

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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

DOI：10.1186/s40779-024-00586-9