Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation

Yi Yang; Tian-Qing Cao; Sheng-Hong He; Lu-Chen Wang; Qi-Heng He; Ling-Zhong Fan; Yong-Zhi Huang; Hao-Ran Zhang; Yong Wang; Yuan-Yuan Dang; Nan Wang; Xiao-Ke Chai; Dong Wang; Qiu-Hua Jiang; Xiao-Li Li; Chen Liu; Shou-Yan Wang

doi:10.1186/s40779-024-00585-w

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Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation

REVIEW | Updated：2025-12-13

- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation
- “Deep brain stimulation (DBS) has shown promise in treating disorders of consciousness (DOC), evolving from an experimental therapy to a detailed modulation approach based on the mesocircuit model hypothesis. Advances in computational models have facilitated a deeper exploration of neural dynamics associated with DOC, linking neuron-level dynamics with macroscopic behavioral changes. Future research should focus on conducting large-scale controlled studies to delve into the pathophysiological mechanisms of DOC.”
- Military Medical Research Vol. 12, Issue 10, Pages: 1542-1566(2025)
- Affiliations：
  
  1.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  2.China National Clinical Research Center for Neurological Diseases, Beijing 100070, China
  3.Innovative Center, Beijing Institute of Brain Disorders, Beijing 100070, China
  4.Department of Neurosur-gery, Chinese Institute for Brain Research, Beijing 100070, China
  5.Medi-cal Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 7BN, UK
  6.Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China
  7.National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
  8.Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
  9.State Key Laboratory of Cognitive Neuroscience and Learn-ing, Beijing Normal University, Beijing 100080, China
  10.Department of Neuro-surgery, Chinese PLA General Hospital, Beijing 100080, China
  11.Department of Neurosurgery, Ganzhou People’s Hospital, Ganzhou 341000, Jiangxi, China
  12.School of Automation Science and Engineering, South China University of Technology, Guangzhou 510641, China
  13.School of Electrical and Informa-tion Engineering, Tianjin University, Tianjin 300072, China
  14.School of Informa-tion Science and Technology, Fudan University, Shanghai 200433, China
- Author bio：
  
  * Yi Yang yangyi_81nk@163.com
  Chen Liu liuchen715@tju.edu.cn
  Shou-Yan Wang shouyan@fudan.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00585-w
  CLC：
- Received：25 March 2024，
  
  Accepted：26 November 2024，
  
  Online First：18 December 2024，
  
  Published：2025-10
- Accepted：
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Yi Yang, Tian-Qing Cao, Sheng-Hong He, et al. Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation[J]. Military Medical Research, 2025, 12(10): 1542-1566.
DOI：

Yi Yang, Tian-Qing Cao, Sheng-Hong He, et al. Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation[J]. Military Medical Research, 2025, 12(10): 1542-1566. DOI： 10.1186/s40779-024-00585-w.

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Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation

DOI：10.1186/s40779-024-00585-w