Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

Kasshish Mehta; Mangala Hegde; Sosmitha Girisa; Ravichandran Vishwa; Mohammed S. Alqahtani; Mohamed Abbas; Mehdi Shakibaei; Gautam Sethi; Ajaikumar B. Kunnumakkara

doi:10.1186/s40779-024-00582-z

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

REVIEW | Updated：2025-12-13

- Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials
- “In the field of triple-negative breast cancer (TNBC) treatment, recent research has made significant progress. Experts have verified the conjecture that targeting tyrosine kinases (TKs) and their receptors can provide solutions to combat TNBC, laying a foundation for the construction of a precision medicine system.”
- Military Medical Research Vol. 12, Issue 8, Pages: 1258-1282(2025)
- Affiliations：
  
  1.Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam 781039, India
  2.Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, 61421 Abha, Saudi Arabia
  3.BioImaging Unit, Space Research Centre, Michael Atiyah Building, University of Leicester, Leicester LE1 7RH, UK
  4.Electrical Engineering Department, College of Engineering, King Khalid University, 61421 Abha, Saudi Arabia
  5.Department of Human-Anatomy, Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Ludwig-Maximilian-University, 80336 Munich, Germany
  6.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
  7.NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117699, Singapore
- Author bio：
  
  * Gautam Sethi phcgs@nus.edu.sg
  Ajaikumar B. Kunnumakkara kunnumakkara@iitg.ac.in
- Funds：
- DOI：10.1186/s40779-024-00582-z
  CLC：
- Received：19 October 2023，
  
  Accepted：08 November 2024，
  
  Online First：12 December 2024，
  
  Published：2025-08
- Accepted：
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Kasshish Mehta, Mangala Hegde, Sosmitha Girisa, et al. Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. Military Medical Research, 2025, 12(8): 1258-1282.
DOI：

Kasshish Mehta, Mangala Hegde, Sosmitha Girisa, et al. Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. Military Medical Research, 2025, 12(8): 1258-1282. DOI： 10.1186/s40779-024-00582-z.

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

DOI：10.1186/s40779-024-00582-z