Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations

Ji-Qian Xu; Wan-Ying Zhang; Jia-Ji Fu; Xiang-Zhi Fang; Cheng-Gang Gao; Chang Li; Lu Yao; Qi-Lan Li; Xiao-Bo Yang; Le-Hao Ren; Hua-Qing Shu; Ke Peng; Ying Wu; Ding-Yu Zhang; Yang Qiu; Xi Zhou; Yong-Ming Yao; You Shang

doi:10.1186/s40779-024-00581-0

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Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations

REVIEW | Updated：2025-12-13

- Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations
- “Reporting on the latest research in the field of sepsis, this review elucidates the definition and diagnosis criteria for viral sepsis, synthesizing current knowledge regarding its etiology, epidemiology, and pathophysiology, molecular mechanisms involved therein as well as their impact on immune-mediated organ damage. Expert discussions on existing therapies and advanced treatment interventions aim to enhance the comprehensive understanding surrounding viral sepsis.”
- Military Medical Research Vol. 12, Issue 9, Pages: 1387-1415(2025)
- Affiliations：
  
  1.Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  2.State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 43007, China
  3.State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan 430072, China
  4.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese, PLA General Hospital, Beijing 100853, China
- Author bio：
  
  * Xi Zhou zhouxi@wh.iov.cn
  Yong-Ming Yao c_ff@sina.com
  You Shang you_shang@hust.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00581-0
  CLC：
- Received：04 March 2024，
  
  Accepted：08 November 2024，
  
  Online First：16 December 2024，
  
  Published：2025-09
- Accepted：
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Ji-Qian Xu, Wan-Ying Zhang, Jia-Ji Fu, et al. Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations[J]. Military Medical Research, 2025, 12(9): 1387-1415.
DOI：

Ji-Qian Xu, Wan-Ying Zhang, Jia-Ji Fu, et al. Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations[J]. Military Medical Research, 2025, 12(9): 1387-1415. DOI： 10.1186/s40779-024-00581-0.

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Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations

DOI：10.1186/s40779-024-00581-0