Understanding immune system dysfunction and its context in mood disorders:psychoneuroimmunoendocrinology and clinical interventions
REVIEW|Updated:2025-12-13
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Understanding immune system dysfunction and its context in mood disorders:psychoneuroimmunoendocrinology and clinical interventions
“Reporting on the latest research in the field of mood disorders, this study delves into the relationship between immune dysfunction and mood disorders within the complex context of psychoneuroimmunoendocrinology (PNIE). The research explores the effects of various clinical strategies on the immune system, aiming to identify mechanisms and potential biomarkers for therapeutic success or failure.”
Military Medical ResearchVol. 12, Issue 9, Pages: 1416-1455(2025)
Affiliations:
1.Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain
2.Ramón y Cajal Institute of Sanitary Research IRYCIS, 28034 Madrid, Spain
3.Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain
4.Department of Nursing and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain
5.Department of Psychiatry and Mental Health, Hospital Universitario Infanta Leonor,28031 Madrid, Spain
6.Psychiatry Service, Center for Biomedical Research in the Mental Health Network, University Hospital Príncipe de Asturias, 28806 Alcalá de Henares, Spain
7.Immune System Diseases-Rheumatology and Internal Medicine Service, University Hospital Príncipe de Asturias, CIBEREHD, 28806 Alcalá de Henares, Spain
Author bio:
* Miguel A. Ortega miguel.angel.ortega92@gmail.com
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, et al. Understanding immune system dysfunction and its context in mood disorders:psychoneuroimmunoendocrinology and clinical interventions[J]. Military Medical Research, 2025, 12(9): 1416-1455.
DOI:
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, et al. Understanding immune system dysfunction and its context in mood disorders:psychoneuroimmunoendocrinology and clinical interventions[J]. Military Medical Research, 2025, 12(9): 1416-1455. DOI: 10.1186/s40779-024-00577-w.
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