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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
RESEARCH | Updated：2025-12-13

    • Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

    • “In the field of sepsis-induced acute lung injury, a novel pathway has been unveiled. Expert research demonstrates that lactate accumulation during sepsis promotes macrophage-derived extracellular CIRP release, which mediates ZBP1-dependent pulmonary vascular endothelial cell PANoptosis, exacerbating ALI. This finding offers new insights into the molecular mechanisms driving sepsis-related pulmonary complications and provides potential new therapeutic strategies.”
    • Military Medical Research   Vol. 12, Issue 7, Pages: 1023-1045(2025)

    • DOI：10.1186/s40779-024-00574-z    

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    • Published：2025-07

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  • Cite this article as: Gong T, Wang QD, Loughran PA, Li YH, Scott MJ, Billiar TR, et al. Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway. Mil Med Res. 2024;11(1):71. DOI： 10.1186/s40779-024-00574-z.

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