Accuracy of cell-free <italic style="font-style: italic">Mycobacterium tuberculosis</italic> DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study

Wei-Li Du; Jian-Qin Liang; Xin-Ting Yang; Cheng-Jun Li; Qing-Feng Wang; Wen-Ge Han; Ye Li; Zhi-Hui Li; Dong-Mei Zhao; Fu-Dong Xu; Yan-Xiao Rong; Xiao-Jing Cui; Hui-Min Li; Feng Wang; Peng-Chong Liu; Dong-Lin Guo; Hai-Bin Wang; Xu-Ya Xing; Jia-Lu Che; Zi-Chen Liu; Na-Na Zhang; Kun Li; Yi Liu; Li Wang; Hai-Bo Wang; Nan-Ying Che

doi:10.1186/s40779-024-00567-y

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Accuracy of cell-free Mycobacterium tuberculosis DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study

RESEARCH | Updated：2025-12-13

- Accuracy of cell-free Mycobacterium tuberculosis DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study
- “In the field of tuberculosis diagnosis, a study involving 11 research sites across China has made significant progress. Experts verified the superior performance of cell-free Mycobacterium tuberculosis DNA testing in diagnosing tuberculous pleurisy, providing a new direction for improving detection rates.”
- Military Medical Research Vol. 12, Issue 7, Pages: 996-1006(2025)
- Affiliations：
  
  1.Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  2.Senior Department of Tuberculosis, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
  3.Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  4.Department of Tuberculosis, Shenyang Tenth People’s Hospital, Shenyang Chest Hospital, Shenyang 110044, China
  5.Department of Tuberculosis, Second People’s Hospital of Weifang, Weifang 261041, Shandong, China
  6.Tuberculosis Department I, Anhui Chest Hospital, Anhui 230022, China
  7.Department of Tuberculosis, Hebei Chest Hospital, Shijiazhuang 050041, China
  8.Department of Tuberculosis, the Infectious Disease Hospital of Heilongjiang Province, Harbin 150500, China
  9.Department of Tuberculosis, the Fifth Hospital of Shijiazhuang, Shijiazhuang 050021, China
  10.Department of Pulmonary and Critical Care Medicine, China Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100029, China
  11.Department of Respiratory Medicine, National Clinical Research Center of Respiratory Disease, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
  12.Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  13.Biobank of Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  14.Beijing Western Medical Branch of PLA General Hospital, Beijing 100091, China
  15.Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing 100191, China
- Author bio：
  
  * wanghb_pucri@bjmu.edu.cn
  chenanying@bjxkyy.cn
- Funds：
- DOI：10.1186/s40779-024-00567-y
  CLC：
- Published：2025-07
- Accepted：
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Cite this article as: Du WL, Liang JQ, Yang XT, Li CJ, Wang QF, Han WG, et al. Accuracy of cell-free Mycobacterium tuberculosis DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study. Mil Med Res. 2024;11(1):60.
DOI：

Cite this article as: Du WL, Liang JQ, Yang XT, Li CJ, Wang QF, Han WG, et al. Accuracy of cell-free Mycobacterium tuberculosis DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study. Mil Med Res. 2024;11(1):60. DOI： 10.1186/s40779-024-00567-y.

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Accuracy of cell-free Mycobacterium tuberculosis DNA testing in pleural effusion for diagnosing tuberculous pleurisy: a multicenter cross-sectional study

DOI：10.1186/s40779-024-00567-y