Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

Babu Santha Aswani; Mangala Hegde; Ravichandran Vishwa; Mohammed S. Alqahtani; Mohamed Abbas; Hassan Ali Almubarak; Gautam Sethi; Ajaikumar B. Kunnumakkara

doi:10.1186/s40779-024-00564-1

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Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

REVIEW | Updated：2025-12-13

- Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases
- “Nuclear receptors (NRs) play a crucial role in development, host defense, and homeostasis. This comprehensive review meticulously examines the involvement of exosome-mediated NRs regulation in the pathogenesis of chronic ailments, including atherosclerosis, cancer, diabetes, liver diseases, and respiratory conditions. Expert xx established the xx system/explored the xx topic/verified the xx conjecture, which provides solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of xx system.”
- Military Medical Research Vol. 12, Issue 7, Pages: 1065-1102(2025)
- Affiliations：
  
  1.Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India
  2.Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, 61421 Abha, Saudi Arabia
  3.BioImaging Unit, Space Research Centre, Michael Atiyah Building, University of Leicester, Leicester LE1 7RH, UK
  4.Electrical Engineering Department, College of Engineering, King Khalid University, 61421 Abha, Saudi Arabia
  5.Division of Radiology, Department of Medicine, College of Medicine and Surgery, King Khalid University, 61421 Abha, Saudi Arabia
  6.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
  7.NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117699, Singapore
- Author bio：
  
  * phcgs@nus.edu.sg
  kunnumakkara@iitg.ac.in
- Funds：
- DOI：10.1186/s40779-024-00564-1
  CLC：
- Published：2025-07
- Accepted：
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Cite this article as: Aswani BS, Hegde M, Vishwa R, Alqahtani MS, Abbas M, Almubarak HA, et al. Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases. Mil Med Res. 2024;11(1):67.
DOI：

Cite this article as: Aswani BS, Hegde M, Vishwa R, Alqahtani MS, Abbas M, Almubarak HA, et al. Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases. Mil Med Res. 2024;11(1):67. DOI： 10.1186/s40779-024-00564-1.

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Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases

DOI：10.1186/s40779-024-00564-1