FDA-approved cannabidiol [Epidiolex<sup>®</sup>] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

Maheedhar Kodali; Leelavathi N. Madhu; Venkata Sai Vashishta Kolla; Sahithi Attaluri; Charles Huard; Yogish Somayaji; Bing Shuai; Chase Jordan; Xiaolan Rao; Sanath Shetty; Ashok K. Shetty

doi:10.1186/s40779-024-00563-2

Your Location：

Home >

Browse articles >

FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

RESEARCH | Updated：2025-12-13

- FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
- “In a study on chronic Gulf War Illness, FDA-approved CBD Epidiolex® was found to alleviate cognitive and mood impairments, as well as hyperalgesia, in rats with chronic GWI. The improvements were attributed to CBD's ability to suppress signaling pathways that perpetuate chronic neuroinflammation.”
- Military Medical Research Vol. 12, Issue 6, Pages: 852-874(2025)
- Affiliations：
  
  Institute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Health Science Center School of Medicine, College Station, TX 77843, USA
- Author bio：
  
  * ash.shetty@tamu.edu
- Funds：
- DOI：10.1186/s40779-024-00563-2
  CLC：
- Published：2025-06
- Accepted：
Scan QR Code
Cite this article as: Kodali M, Madhu LN, Kolla VSV, Attaluri S, Huard C, Somayaji Y, et al. FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis. Mil Med Res. 2024;11(1):61.
DOI：

Cite this article as: Kodali M, Madhu LN, Kolla VSV, Attaluri S, Huard C, Somayaji Y, et al. FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis. Mil Med Res. 2024;11(1):61. DOI： 10.1186/s40779-024-00563-2.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts

Advances in the mechanism of small nucleolar RNA and its role in DNA damage response

Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering

Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

Related Author

Han Han

Hao Jia

Yi-Fan Wang

Jiang-Ping Song

Li-Ping Shen

Wen-Cheng Zhang

Jia-Rong Deng

Zhen-Hua Qi

Related Institution

Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, National Centre for Cardiovascular Disease; Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine

Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China

Department of Biomedical Engineering, Texas A&M University, College Station

Department of Immunology, School of Basic Medical Sci-ences, Tianjin Medical University

⁰

FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

DOI：10.1186/s40779-024-00563-2

FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis