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Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
RESEARCH | Updated：2025-12-13

    • Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

    • “In the field of cardiovascular surgery, a phase 3 trial of tetracosactide (TCS10) targeting melanocortin receptors (MCRs) demonstrated significant improvement in 30-day mortality and reduced blood transfusion episodes. Expert sensitivity analysis using the Naïve Bayes classifier and density-based sensitivity index provides a new direction for improving surgical rescue outcomes in critically ill patients.”
    • Military Medical Research   Vol. 12, Issue 6, Pages: 836-851(2025)

    • DOI：10.1186/s40779-024-00555-2    

      CLC：

    • Published：2025-06

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  • Cite this article as: Noera G, Bertolini A, Calzà L, Gori M, Pitino A, D’Arrigo G, et al. Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial. Mil Med Res. 2024;11(1):56. DOI： 10.1186/s40779-024-00555-2.

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Related Institution

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