PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

Cheng-Qing Hu; Tao Hou; Rui Xiang; Xin Li; Jing Li; Tian-Tian Wang; Wen-Jun Liu; Song Hou; Di Wang; Qing-He Zhao; Xiao-Xing Yu; Ming Xu; Xing-Kai Liu; Yu-Jing Chi; Ji-Chun Yang

doi:10.1186/s40779-024-00543-6

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PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

RESEARCH | Updated：2025-12-13

- PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
- “In a groundbreaking study, researchers unveil the pivotal role of PANX1-mediated ATP release in maintaining hepatic glucolipid homeostasis, shedding light on FAM3A's suppressive effects on hepatic gluconeogenesis and lipogenesis.”
- Military Medical Research Vol. 12, Issue 5, Pages: 659-685(2025)
- Affiliations：
  
  1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences/State Key Laboratory of Vascular Homeostasis and Remodeling/Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  2.Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China
  3.Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  4.Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, China
  5.Department of Gastroenterology, Peking University People’s Hospital, Beijing 100044, China
  6.Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital/Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education, Beijing 100191, China
  7.Department of Hepatobiliary and Pancreatic Surgery, General Surgery Centre, the First Hospital of Jilin University, Changchun 130061, China
  8.Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
- Author bio：
  
  * xingkailiu@foxmail.com
  chiyujing@bjmu.edu.cn
  yangj@bjmu.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00543-6
  CLC：
- Published：2025-05
- Accepted：
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Cite this article as: Hu CQ, Hou T, Xiang R, Li X, Li J, Wang TT, et al. PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis. Mil Med Res. 2024;11(1):41.
DOI：

Cite this article as: Hu CQ, Hou T, Xiang R, Li X, Li J, Wang TT, et al. PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis. Mil Med Res. 2024;11(1):41. DOI： 10.1186/s40779-024-00543-6.

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PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

DOI：10.1186/s40779-024-00543-6