Advancing skeletal health and disease research with single-cell RNA sequencing

Peng Lin; Yi-Bo Gan; Jian He; Si-En Lin; Jian-Kun Xu; Liang Chang; Li-Ming Zhao; Jun Zhu; Liang Zhang; Sha Huang; Ou Hu; Ying-Bo Wang; Huai-Jian Jin; Yang-Yang Li; Pu-Lin Yan; Lin Chen; Jian-Xin Jiang; Peng Liu

doi:10.1186/s40779-024-00538-3

Your Location：

Home >

Browse articles >

Advancing skeletal health and disease research with single-cell RNA sequencing

REVIEW | Updated：2025-12-13

- Advancing skeletal health and disease research with single-cell RNA sequencing
- “In the field of orthopedics, a comprehensive review presents a streamlined approach to obtaining high-quality single cells from skeletal tissue and provides an overview of existing single-cell RNA sequencing technologies employed in skeletal studies along with practical bioinformatic analysis pipelines. This research has paved the way for discovering novel therapeutic targets that offer potential benefits to patients suffering from diverse skeletal disorders.”
- Military Medical Research Vol. 12, Issue 2, Pages: 285-310(2025)
- Affiliations：
  
  1.Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
  2.Pancreatic Injury and Repair Key Laboratory of Sichuan Province, the General Hospital of Western Theater Command, Chengdu 610031, China
  3.Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China
  4.Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Sacramento, CA 94305, USA
  5.Center of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Daping Hospital, Army Medical University, Chongqing 400042, China
  6.Wound Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
- Author bio：
  
  *jiangjx@cta.cq.cn;
  liupengd@tmmu.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00538-3
  CLC：
- Published：2025-02
- Accepted：
Scan QR Code
Cite this article as: Lin P, Gan YB, He J, Lin SE, Xu JK, Chang L, et al. Advancing skeletal health and disease research with single-cell RNA sequencing. Mil Med Res. 2024;11(1):33.
DOI：

Cite this article as: Lin P, Gan YB, He J, Lin SE, Xu JK, Chang L, et al. Advancing skeletal health and disease research with single-cell RNA sequencing. Mil Med Res. 2024;11(1):33. DOI： 10.1186/s40779-024-00538-3.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy

Research on the Measurement System of the Attack Angle between Wheel and Rail Based on Image Identification

Digital Demodulation Method for Multi-tone FM Signal in Track Circuit System

Research on Driving Equipment Suspension Parameters and the Structures of Locomotives with Motor Elastically Mounted on the Frame

Related Author

Lu Yang

Qiang Wei

Shi Qiu

Ping Han

Jia You

Qiao Xiong

Xu Shi

Deng-Xiong Li

Related Institution

Department of Urology, Institute of Urology, West China Hospital, Sichuan University

Division of Surgery & Interventional Science, University College London

Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Centre for Disease-Related Molecular Network, Department of General Surgery, West China Hospital, Sichuan University

Department of Oncology, West China School of Public Health and West China Fourth Hospital, Sichuan University

Department of Rheumatology and Immunology, Rare Diseases Centre, West China Hospital, Sichuan University

⁰

Advancing skeletal health and disease research with single-cell RNA sequencing

DOI：10.1186/s40779-024-00538-3