Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Xian-Bin Zhang; Yi-Bao Fan; Rui Jing; Mikiyas Amare Getu; Wan-Ying Chen; Wei Zhang; Hong-Xia Dong; Tikam Chand Dakal; Akhtar Hayat; Hua-Jun Cai; Milad Ashrafizadeh; A. M. Abd El-Aty; Ahmet Hacimuftuoglu; Peng Liu; Tian-Feng Li; Gautam Sethi; Kwang Seok Ahn; Yavuz Nuri Ertas; Min-Jiang Chen; Jian-Song Ji; Li Ma; Peng Gong

doi:10.1186/s40779-024-00535-6

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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

REVIEW | Updated：2025-12-13

- Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
- “Reporting on the latest research in the field of neuroendocrine neoplasms, this review highlights the limitations and recent advancements in understanding the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of gastroenteropancreatic NENs, which provides solutions to solve the delays in diagnosis and timely treatment of these patients.”
- Military Medical Research Vol. 12, Issue 4, Pages: 579-599(2025)
- Affiliations：
  
  1.Department of General SurgeryInstitute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, Guangdong, China
  2.School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, Guangdong, China
  3.Department of Radiology, Second Hospital of Shandong University, Jinan 250000, China
  4.Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China
  5.Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, India
  6.Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan
  7.Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
  8.Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey
  9.Reproductive Medicine Center, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518055, Guangdong, China
  10.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
  11.Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
  12.ERNAM-Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye
  13.Department of Biomedical Engineering, Erciyes University, Kayseri 38280, Türkiye
  14.UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye
  15.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China
  16.Department of Epidemiology, Dalian Medical University, Dalian 116044, Liaoning, China
- Author bio：
  
  *doctorgongpeng@szu.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00535-6
  CLC：
- Published：2025-04
- Accepted：
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Cite this article as: Zhang XB, Fan YB, Jing R, Getu MA, Chen WY, Zhang W, et al. Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives. Mil Med Res. 2024;11(1):35.
DOI：

Cite this article as: Zhang XB, Fan YB, Jing R, Getu MA, Chen WY, Zhang W, et al. Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives. Mil Med Res. 2024;11(1):35. DOI： 10.1186/s40779-024-00535-6.

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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

DOI：10.1186/s40779-024-00535-6