<italic style="font-style: italic">P. gingivalis</italic> in oral-prostate axis exacerbates benign prostatic hyperplasia <italic style="font-style: italic">via</italic> IL-6/IL-6R pathway

Shuang-Ying Wang; Yi Cai; Xiao Hu; Fei Li; Xin-Hang Qian; Ling-Yun Xia; Bo Gao; Lan Wu; Wen-Zhong Xie; Jia-Min Gu; Tong Deng; Cong Zhu; Hai-Chang Jia; Wan-Qi Peng; Jiao Huang; Cheng Fang; Xian-Tao Zeng

doi:10.1186/s40779-024-00533-8

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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

RESEARCH | Updated：2025-12-13

- P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
- “In the field of benign prostatic hyperplasia (BPH), a study led by experts has explored the role and mechanism of Porphyromonas gingivalis (P. gingivalis) in the development of BPH. The research found that P. gingivalis infection can promote BPH, which may affect the progression of BPH via inflammation and the Akt signaling pathway.”
- Military Medical Research Vol. 12, Issue 4, Pages: 469-487(2025)
- Affiliations：
  
  1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  3.Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China
  4.Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
  5.Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
  6.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  7.Henan Provincial Engineering Research Center for Microecological Regulatory of Oral Environment and Oral Implantology, Kaifeng University Health Science Center, Kaifeng 475000, Henan, China
  8.School of Stomatology, Jinan University, Guangzhou 510632, China
- Author bio：
  
  *huangjiao1019@163.com;
  vitsippa@whu.edu.cn;
  zengxiantao1128@163.com
- Funds：
- DOI：10.1186/s40779-024-00533-8
  CLC：
- Published：2025-04
- Accepted：
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Cite this article as: Wang SY, Cai Y, Hu X, Li F, Qian XH, Xia LY, et al. P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway. Mil Med Res. 2024;11(1):30.
DOI：

Cite this article as: Wang SY, Cai Y, Hu X, Li F, Qian XH, Xia LY, et al. P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway. Mil Med Res. 2024;11(1):30. DOI： 10.1186/s40779-024-00533-8.

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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

DOI：10.1186/s40779-024-00533-8