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CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
LETTER TO THE EDITOR | Updated：2025-12-13

    • CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations

    • “In the field of xxx, expert xx has made significant progress. They established the xx system/explored the xx topic/verified the xx conjecture, offering solutions to tackle xx problems and paving the way for future research in xx.”
    • Military Medical Research   Vol. 12, Issue 5, Pages: 803-806(2025)

    • DOI：10.1186/s40779-024-00530-x    

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    • Published：2025-05

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  • Cite this article as: Fan XW, Gao ZF, Ling DD, Wang DH, Cui Y, Du HQ, et al. CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations. Mil Med Res. 2024;11(1):25. DOI： 10.1186/s40779-024-00530-x.

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