“In the field of intervertebral disc degeneration (IVDD), a study has made significant progress. The research team optimized mannose concentration for restoring nucleus pulposus (NP) cells, identified the key gene TXNIP, and elucidated the mechanism of action of mannose through the TXNIP-glutamine axis. This study provides strong evidence supporting the potential of mannose in clinical applications for alleviating IVDD, offering a more advantageous approach compared to existing therapies.”