The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

De-Chao Feng; Wei-Zhen Zhu; Jie Wang; Deng-Xiong Li; Xu Shi; Qiao Xiong; Jia You; Ping Han; Shi Qiu; Qiang Wei; Lu Yang

doi:10.1186/s40779-024-00526-7

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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

REVIEW | Updated：2025-12-13

- The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
- “Advancements in single-cell and spatial transcriptomics have enabled a detailed molecular comprehension of the complex regulation of cell fate, significantly contributing to the development of personalized medicine. This review outlines the significance of single-cell RNA sequencing (scRNA-seq) in prostate cancer research, highlighting key molecular targets for diagnosis, treatment, and drug resistance characteristics. These studies are expected to provide novel insights for the development of immunotherapy and other innovative treatment strategies for castration-resistant prostate cancer.”
- Military Medical Research Vol. 12, Issue 2, Pages: 220-241(2025)
- Affiliations：
  
  1.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  2.Division of Surgery & Interventional Science, University College London, London WC1E 6BT, UK
- Author bio：
  
  *fdcfenix@stu.scu.edu.cn; dechao.feng@ucl.ac.uk;
  weiqiang@scu.edu.cn;
  wyclefue@scu.edu.cn
- Funds：
- DOI：10.1186/s40779-024-00526-7
  CLC：
- Published：2025-02
- Accepted：
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Cite this article as: Feng DC, Zhu WZ, Wang J, Li DX, Shi X, Xiong Q, et al. The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy. Mil Med Res. 2024;11(1):21.
DOI：

Cite this article as: Feng DC, Zhu WZ, Wang J, Li DX, Shi X, Xiong Q, et al. The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy. Mil Med Res. 2024;11(1):21. DOI： 10.1186/s40779-024-00526-7.

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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

DOI：10.1186/s40779-024-00526-7