Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
RESEARCH|Updated:2025-12-13
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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
“In the field of liver ischemia/reperfusion injury, this study introduces its research progress. Expert xx verified the conjecture that interferon-α stimulates DHX58 to promote the translation of m6A-modified Gpx4 mRNA, which provides solutions to prevent hepatic ferroptosis during liver I/R injury.”
Military Medical ResearchVol. 12, Issue 2, Pages: 184-203(2025)
Affiliations:
1.National Key Laboratory of Medical Immunology & Institute of Immunology, Naval Medical University, Shanghai 200433, China
2.Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
3.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100853, China
4.Center for Immunotherapy, Chinese Academy of Medical Sciences, Beijing 100005, China
Cite this article as: Jia KW, Yao RQ, Fan YW, Zhang DJ, Zhou Y, Wang MJ, et al. Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Mil Med Res. 2024;11(1):22.
DOI:
Cite this article as: Jia KW, Yao RQ, Fan YW, Zhang DJ, Zhou Y, Wang MJ, et al. Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Mil Med Res. 2024;11(1):22. DOI: 10.1186/s40779-024-00524-9.
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis