Endophilin A2 controls touch and mechanical allodynia <italic style="font-style: italic">via</italic> kinesin-mediated Piezo2 trafficking

Man-Xiu Xie; Ren-Chun Lai; Yi-Bin Xiao; Xi Zhang; Xian-Ying Cao; Xiao-Yu Tian; An-Nan Chen; Zi-Yi Chen; Yan Cao; Xiao Li; Xiao-Long Zhang

doi:10.1186/s40779-024-00520-z

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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

RESEARCH | Updated：2025-12-13

- Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
- “In the field of mechanical pain research, the KIF5B/EndoA2/Piezo2 complex is essential for Piezo2 trafficking and sustaining transmission of touch and mechanical hypersensitivity signals. Expert EndoA2 regulates touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking in sensory neurons, which provides a potential new target for the treatment of mechanical pain.”
- Military Medical Research Vol. 12, Issue 2, Pages: 157-183(2025)
- Affiliations：
  
  1.Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China
  2.Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China
  3.Pain Research Center and Department of Physiology, Zhongshan School of Medicine of Sun Yat-sen University, Guangzhou 510080, China
  4.Engineering Technology Research Center for Elderly Health Management in Hainan Province, Haikou 571137, China
  5.College of Food Science and Technology, Hainan University, Haikou 570228, China
- Author bio：
  
  *zhangxiaolong@gdph.org.cn
- Funds：
- DOI：10.1186/s40779-024-00520-z
  CLC：
- Published：2025-02
- Accepted：
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Cite this article as: Xie MX, Lai RC, Xiao YB, Zhang X, Cao XY, Tian XY, et al. Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking. Mil Med Res. 2024;11(1):17.
DOI：

Cite this article as: Xie MX, Lai RC, Xiao YB, Zhang X, Cao XY, Tian XY, et al. Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking. Mil Med Res. 2024;11(1):17. DOI： 10.1186/s40779-024-00520-z.

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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

DOI：10.1186/s40779-024-00520-z