Acellular scaffold-based approach for <italic style="font-style: italic">in situ</italic> genetic engineering of host T-cells in solid tumor immunotherapy

Hiren Y. Dandia; Mamatha M. Pillai; Deepak Sharma; Meghna Suvarna; Neha Dalal; Ayush Madhok; Arvind Ingle; Shubhada V. Chiplunkar; Sanjeev Galande; Prakriti Tayalia

doi:10.1186/s40779-023-00503-6

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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

RESEARCH | Updated：2025-02-24

- Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
- “Targeted T-cell therapy has made significant progress in treating hematological malignancies, but faces challenges in solid tumors. Experts have developed a polyethylene glycol-based 3D scaffold system, which provides an innovative in situ localized approach for programming T-cells to target solid tumors, offering a viable alternative to in vitro manipulation of T-cells.”
- Military Medical Research Vol. 12, Issue 1, Pages: 16-35(2025)
- Affiliations：
  
  1.Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
  2.Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India
  3.Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India
  4.Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Mumbai 410210, India
- Author bio：
  
  *prakriti@iitb.ac.in
- Funds：
- DOI：10.1186/s40779-023-00503-6
  CLC：
- Published：2025-01
- Accepted：
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Cite this article as: Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3.
DOI：

Cite this article as: Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3. DOI： 10.1186/s40779-023-00503-6.

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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

DOI：10.1186/s40779-023-00503-6