Elevated FBXL6 activates both wild-type KRAS and mutant KRAS<sup>G12D</sup> and drives HCC tumorigenesis <italic style="font-style: italic">via</italic> the ERK/mTOR/PRELID2/ROS axis in mice

Your Location：

Home >

Browse articles >

Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice

RESEARCH | Updated：2025-12-13

- Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
- “In the field of liver cancer research, this study investigates how FBXL6 regulates KRAS and KRASG12D activity in hepatocellular carcinoma. Expert established the FBXL6/KRAS/ERK/mTOR/PRELID2/ROS axis, which provides a potential therapeutic strategy to treat aggressive liver cancer.”
- Military Medical Research Vol. 11, Issue 6, Pages: 818-838(2024)
- Affiliations：
  
  Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing 400038, China
- Author bio：
  
  *cmxie@tmmu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00501-8
  CLC：
- Published：2024-12
- Accepted：
Scan QR Code
Cite this article as: Xiong HJ, Yu HQ, Zhang J, Fang L, Wu D, Lin XT, et al. Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice. Mil Med Res. 2023;10(1):68.
DOI：

Cite this article as: Xiong HJ, Yu HQ, Zhang J, Fang L, Wu D, Lin XT, et al. Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice. Mil Med Res. 2023;10(1):68. DOI： 10.1186/s40779-023-00501-8.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells

Kalman Dynamic Adaptive Filtering to Railway Line Measurement Signals of Tilting Train

Coupling Vibration Analysis on Yuxi River Bridge of Wuhu Yangtze River Bridge

Research on Reinforcement Technique to Enhance Lateral Stiffness of Steel Truss Bridge on Existing Railway

Related Author

Jie Fan

You-Tan Liu

Ting Gong

Timothy R. Billiar

Melanie J. Scott

Yue-Hua Li

Patricia A. Loughran

Qing-De Wang

Related Institution

Research and Development, Veterans Affairs Pittsburgh Healthcare System

Department of Immunology, University of Pittsburgh School of Medicine

McGowan Institute for Regenerative Medicine, University of Pittsburgh

Department of Anesthesiology, Shenzhen Hospital of Southern Medical University

Department of Surgery, University of Pittsburgh School of Medicine

⁰

Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice