Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

REVIEW | Updated：2025-12-13

- Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
- “In the field of cancer immunotherapy, researchers have summarized the epigenetic mechanisms leading to T cell exhaustion in the tumor microenvironment and discussed the therapeutic potential of targeting epigenetic regulators for immunotherapies. This lays a foundation for the construction of treatment paradigms involving immunostimulatory agents and epigenetic therapies.”
- Military Medical Research Vol. 11, Issue 6, Pages: 863-886(2024)
- Affiliations：
  
  1.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430079, China
  2.Department of Oral Maxillofacial-Head Neck Oncology, School and and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
- Author bio：
  
  *luzhang2012@whu.edu.cn;
  sunzj@whu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00496-2
  CLC：
- Published：2024-12
- Accepted：
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Cite this article as: Xiong D, Zhang L, Sun ZJ. Targeting the epigenome to reinvigorate T cells for cancer immunotherapy. Mil Med Res. 2023;10(1):59.
DOI：

Cite this article as: Xiong D, Zhang L, Sun ZJ. Targeting the epigenome to reinvigorate T cells for cancer immunotherapy. Mil Med Res. 2023;10(1):59. DOI： 10.1186/s40779-023-00496-2.

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