Targeting NR1D1 in organ injury: challenges and prospects

Zi-Yin Zhang-Sun; Xue-Zeng Xu; Germaine Escames; Wang-Rui Lei; Lin Zhao; Ya-Zhe Zhou; Ye Tian; Ya-Nan Ren; Darío Acuña-Castroviejo; Yang Yang

doi:10.1186/s40779-023-00495-3

Your Location：

Home >

Browse articles >

Targeting NR1D1 in organ injury: challenges and prospects

REVIEW | Updated：2025-12-13

- Targeting NR1D1 in organ injury: challenges and prospects
- “Nuclear receptor NR1D1, a key transcription factor in the circadian clock, plays a crucial role in regulating downstream target genes involved in autophagy, immunity, inflammation, metabolism, and aging. This review highlights the latest milestones in NR1D1 ligand research, which may pave the way for their clinical application in treating diverse organ injury-related diseases.”
- Military Medical Research Vol. 11, Issue 6, Pages: 887-906(2024)
- Affiliations：
  
  1.Department of Cardiology, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  2.Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  3.Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  4.Biomedical Research Center, Department of Physiology, Faculty of Medicine, Institute of Biotechnology, Technological Park of Health Sciences, University of Granada, 18016 Granada, Spain
  5.Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Ibs.Granada, San Cecilio University Hospital, 18016 Granada, Spain
  6.UGC of Clinical Laboratories, San Cecilio Clinical University Hospital, 18016 Granada, Spain
- Author bio：
  
  *dacuna@ugr.es;
  yang200214yy@nwu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00495-3
  CLC：
- Published：2024-12
- Accepted：
Scan QR Code
Cite this article as: Zhang-Sun ZY, Xu XZ, Escames G, Lei WR, Zhao L, Zhou YZ, et al. Targeting NR1D1 in organ injury: challenges and prospects. Mil Med Res. 2023;10(1):62.
DOI：

Cite this article as: Zhang-Sun ZY, Xu XZ, Escames G, Lei WR, Zhao L, Zhou YZ, et al. Targeting NR1D1 in organ injury: challenges and prospects. Mil Med Res. 2023;10(1):62. DOI： 10.1186/s40779-023-00495-3.

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Spatial transcriptomics: recent developments and insights in respiratory research

Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research

Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

Kalman Dynamic Adaptive Filtering to Railway Line Measurement Signals of Tilting Train

Fracture Load Test and Spatial Analysis for the Full Scale Model of Underground Viaduct Channel Girder

Related Author

Xiang-Wei Zhao

Zhou-Guang Wang

Qin-Yu Ge

Chen Gao

Kai-Tong Dang

Ming-Jing Zhang

Li-Yong He

Liu-Xi Chu

Related Institution

Orthopaedic Bioengineering Research Group, Division of Surgery and Interventional Science, University College London

Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University

Yaneng BIOScience (Shenzhen) Co., Ltd.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics

⁰

Targeting NR1D1 in organ injury: challenges and prospects

DOI：10.1186/s40779-023-00495-3