Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

Meng-Yuan Jiang; Wan-Rong Man; Xue-Bin Zhang; Xiao-Hua Zhang; Yu Duan; Jie Lin; Yan Zhang; Yang Cao; De-Xi Wu; Xiao-Fei Shu; Lei Xin; Hao Wang; Xiao Zhang; Cong-Ye Li; Xiao-Ming Gu; Xuan Zhang; Dong-Dong Sun

doi:10.1186/s40779-023-00493-5

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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

RESEARCH | Updated：2025-12-13

- Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
- “In the field of diabetic cardiomyopathy, researchers have made significant progress. They found that Adipsin improves fatty acid β-oxidation and alleviates mitochondrial injury in DCM, with the mechanism related to Irak2 interaction and inhibition of Irak2 mitochondrial translocation.”
- Military Medical Research Vol. 11, Issue 5, Pages: 625-642(2024)
- Affiliations：
  
  1.Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  2.Department of Basic Medicine, Air Force Medical University, Xi’an 710032, China
  3.Department of Physiology and Pathophysiology, Air Force Medical University, Xi’an 710032, China
  4.Institute for Hospital Management Research, Chinese PLA General Hospital, Beijing 100853, China
- Author bio：
  
  *zhangxuan@301hospital.com.cn;
  wintersun3@fmmu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00493-5
  CLC：
- Published：2024-10
- Accepted：
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Cite this article as: Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, et al. Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy. Mil Med Res. 2023;10(1):63.
DOI：

Cite this article as: Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, et al. Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy. Mil Med Res. 2023;10(1):63. DOI： 10.1186/s40779-023-00493-5.

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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

DOI：10.1186/s40779-023-00493-5