The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

Na Li; Ling Wang; Lei Li; Meng-Zhao Yang; Qing-Xiang Wang; Xi-Wen Bai; Feng Gao; Yi-Qiang Yuan; Zu-Jiang Yu; Zhi-Gang Ren

doi:10.1186/s40779-023-00489-1

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The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

REVIEW | Updated：2025-12-13

- The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
- Military Medical Research Vol. 11, Issue 5, Pages: 697-716(2024)
- Affiliations：
  
  1.Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  2.Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250000, China
  3.Department of Cardiovascular Medicine, Henan Provincial Chest Hospital, Zhengzhou 450008, China
  4.Department of Blood Collection, Xuchang Blood Center, Xuchang 461000, Henan, China
  5.Nanchang University Queen Marry School, Nanchang 330036, China
- Author bio：
  
  *xkyuanyq@zzu.edu.cn;
  johnyuem@zzu.edu.cn;
  fccrenzg@zzu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00489-1
  CLC：
- Published：2024-10
- Accepted：
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Cite this article as: Li N, Wang L, Li L, Yang MZ, Wang QX, Bai XW, et al. The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives. Mil Med Res. 2023;10(1):51.
DOI：

Cite this article as: Li N, Wang L, Li L, Yang MZ, Wang QX, Bai XW, et al. The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives. Mil Med Res. 2023;10(1):51. DOI： 10.1186/s40779-023-00489-1.

摘要

Abstract

Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however

the mechanisms are not entirely clarified. It is gaining awareness that alterations in the assembly

structure

and dynamics of gut microbiota are intimately engaged in the AF progression. Owing to advancements in next-generation sequencing technologies and computational strategies

researchers can explore novel linkages with the genomes

transcriptomes

proteomes

and metabolomes through parallel meta-omics approaches

rendering a panoramic view of the culture-independent microbial investigation. In this review

we summarized the evidence for a bidirectional correlation between AF and the gut microbiome. Furthermore

we proposed the concept of "gut-immune-heart" axis and addressed the direct and indirect causal roots between the gut microbiome and AF. The intricate relationship was unveiled to generate innovative microbiota-based preventive and therapeutic interventions

which shed light on a definite direction for future experiments.

关键词

Keywords

references

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