How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology

Wen-Qiang Che; Yuan-Jie Li; Chi-Kwan Tsang; Yu-Jiao Wang; Zheng Chen; Xiang-Yu Wang; An-Ding Xu; Jun Lyu

doi:10.1186/s40779-023-00488-2

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How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology

REVIEW | Updated：2025-12-13

- How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology
- Military Medical Research Vol. 11, Issue 5, Pages: 686-696(2024)
- Affiliations：
  
  1.Department of Neurosurgery, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  2.Department of Clinical Research, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  3.Planning & Discipline Construction Office, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  4.Clinical Neuroscience Institute, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  5.Department of Pathology, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
  6.Department of Urology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  7.Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  8.Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Guangzhou 510632, China
- Author bio：
  
  *wang_xy123@126.com;
  tlil@jnu.edu.cn;
  lyujun2020@jnu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00488-2
  CLC：
- Published：2024-10
- Accepted：
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Cite this article as: Che WQ, Li YJ, Tsang CK, Wang YJ, Chen Z, Wang XY, et al. How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology. Mil Med Res. 2023;10(1):50.
DOI：

Cite this article as: Che WQ, Li YJ, Tsang CK, Wang YJ, Chen Z, Wang XY, et al. How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology. Mil Med Res. 2023;10(1):50. DOI： 10.1186/s40779-023-00488-2.

摘要

Abstract

In the United States (US)

the Surveillance

Epidemiology

and End Results (SEER) program is the only comprehensive source of population-based information that includes stage of cancer at the time of diagnosis and patient survival data. This program aims to provide a database about cancer incidence and survival for studies of surveillance and the development of analytical and methodological tools in the cancer field. Currently

the SEER program covers approximately half of the total cancer patients in the US. A growing number of clinical studies have applied the SEER database in various aspects. However

the intrinsic features of the SEER database

such as the huge data volume and complexity of data types

have hindered its application. In this review

we provided a systematic overview of the commonly used methodologies and study designs for retrospective epidemiological research in order to illustrate the application of the SEER database. Therefore

the goal of this review is to assist researchers in the selection of appropriate methods and study designs for enhancing the robustness and reliability of clinical studies by mining the SEER database.

关键词

Keywords

references

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