Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

Lu Tang; Zhong-Pei Huang; Heng Mei; Yu Hu

doi:10.1186/s40779-023-00486-4

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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

REVIEW | Updated：2025-12-13

- Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
- “Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic malignancies. However, progress is still hindered as clinical benefit is only available for a fraction of patients. In this review, we discuss the reasons why CAR-T immunotherapy fails in clinical practice and what this field has learned since the milestone of single-cell sequencing technologies. Expert xx established the xx system/explored the xx topic/verified the xx conjecture, which provides solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of xx system.”
- Military Medical Research Vol. 11, Issue 5, Pages: 717-746(2024)
- Affiliations：
  
  1.Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  2.Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan 430022, China
  3.Key Laboratory of Biological Targeted Therapy, the Ministry of Education, Wuhan 430022, China
  4.Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Author bio：
  
  *hmei@hust.edu.cn;
  dr_huyu@126.com
- Funds：
- DOI：10.1186/s40779-023-00486-4
  CLC：
- Published：2024-10
- Accepted：
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Cite this article as: Tang L, Huang ZP, Mei H, Hu Y. Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer. Mil Med Res. 2023;10(1):52.
DOI：

Cite this article as: Tang L, Huang ZP, Mei H, Hu Y. Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer. Mil Med Res. 2023;10(1):52. DOI： 10.1186/s40779-023-00486-4.

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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

DOI：10.1186/s40779-023-00486-4