Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

Shuai Hao; He Huang; Rui-Yan Ma; Xue Zeng; Chen-Yang Duan

doi:10.1186/s40779-023-00482-8

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Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

REVIEW | Updated：2025-12-13

- Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy
- “Reporting on the latest research, experts have summarized recent findings on the oligomeric changes, modification types, and protein interactions of Dynamin-related protein 1 (Drp1) in various hypoxic-ischemic diseases, which provides new ideas and targets for proactive interventions on multiple organ damage induced by these conditions.”
- Military Medical Research Vol. 11, Issue 4, Pages: 589-615(2024)
- Affiliations：
  
  1.Department of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  2.Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
  3.Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China
  4.Institute for Brain Science and Disease, Chongqing Medical University, Chongqing 400010, China
- Author bio：
  
  Shuai Hao, He Huang, Rui-Yan Ma, and Xue Zeng contributed equally to this work
  *duanchenyang1991@cqmu.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00482-8
  CLC：
- Published：2024-08
- Accepted：
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Cite this article as: Hao S, Huang H, Ma RY, Zeng X, Duan CY. Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy. Mil Med Res. 2023;10(1):46.
DOI：

Cite this article as: Hao S, Huang H, Ma RY, Zeng X, Duan CY. Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy. Mil Med Res. 2023;10(1):46. DOI： 10.1186/s40779-023-00482-8.

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Multifaceted functions of Drp1 in hypoxia/ischemia- induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy

DOI：10.1186/s40779-023-00482-8