Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

Jia-Yi Ding; Min-Jiang Chen; Ling-Feng Wu; Gao-Feng Shu; Shi-Ji Fang; Zhao-Yu Li; Xu-Ran Chu; Xiao-Kun Li; Zhou-Guang Wang; Jian-Song Ji

doi:10.1186/s40779-023-00472-w

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

REVIEW | Updated：2025-12-13

- Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges
- “Reporting on the latest advancements in wound repair, a comprehensive overview highlights the significant potential of mesenchymal stem cell-derived extracellular vesicles in promoting skin wound healing. Expert research has established the therapeutic application of these vesicles, which can regenerate vessels, nerves, and hair follicles, inhibit scar formation, and serve as a scaffold for wound repair components. This exploration lays a foundation for the construction of a clinical treatment system for wound repair.”
- Military Medical Research Vol. 11, Issue 3, Pages: 400-429(2024)
- Affiliations：
  
  1.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Zhejiang, Lishui 323000, China
  2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China
  3.Clinical College of the Affiliated Central Hospital, School of Medicine, Lishui University, Lishui 323000, Zhejiang, China
  4.Department of Overseas Education College, Jimei University, Xiamen 361021, Fujian, China
  5.Department of Medicine II, Internal Medicine, Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giessen, Germany
  6.Pulmonary and Critical Care, Department of Medicine V, Internal Medicine, Infectious Diseases and Infection Control, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giessen, Germany
- Author bio：
  
  *xiaokunli@wmu.edu.cn; lixk1964@163.com;
  wangzhouguang@wmu.edu.cn; wzhouguang@gmail.com;
  jijiansong@zju.edu.cn
- Funds：
- DOI：10.1186/s40779-023-00472-w
  CLC：
- Published：2024-06
- Accepted：
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Cite this article as: Ding JY, Chen MJ, Wu LF, Shu GF, Fang SJ, Li ZY, et al. Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges. Mil Med Res. 2023;10(1):36.
DOI：

Cite this article as: Ding JY, Chen MJ, Wu LF, Shu GF, Fang SJ, Li ZY, et al. Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges. Mil Med Res. 2023;10(1):36. DOI： 10.1186/s40779-023-00472-w.

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges

DOI：10.1186/s40779-023-00472-w