RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

Yi-Qun Li; Fang-Zhou Sun; Chun-Xiao Li; Hong-Nan Mo; Yan-Tong Zhou; Dan Lv; Jing-Tong Zhai; Hai-Li Qian; Fei Ma

doi:10.1186/s40779-023-00470-y

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

RESEARCH | Updated：2025-12-13

- RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
- “In the field of triple negative breast cancer brain metastasis, researchers have identified and verified the specific down-regulation of retinoic acid receptor responder 2 (RARRES2) in brain metastasis of TNBC. The study found that RARRES2 deficiency promotes BCBrM through lipid metabolic reprogramming, providing potential biomarkers or therapeutic targets for BCBrM.”
- Military Medical Research Vol. 11, Issue 1, Pages: 34-49(2024)
- Affiliations：
  
  1.Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  2.State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Author bio：
  
  * qianhaili@pumc.edu.cn,
  mafei@cicams.ac.cn
- Funds：
- DOI：10.1186/s40779-023-00470-y
  CLC：
- Published：2024-02
- Accepted：
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Cite this article as: Li YQ, Sun FZ, Li CX, Mo HN, Zhou YT, Lv D, et al. RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer. Mil Med Res. 2023;10(1):34.
DOI：

Cite this article as: Li YQ, Sun FZ, Li CX, Mo HN, Zhou YT, Lv D, et al. RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer. Mil Med Res. 2023;10(1):34. DOI： 10.1186/s40779-023-00470-y.

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

DOI：10.1186/s40779-023-00470-y